Effects of corn resistant starch on metabolic syndrome and gut microbiota in high-fat diet-induced obese mice
Abstract
Resistant starch, a type of dietary fiber, not only ameliorates obesity but also promotes production of short-chain fatty acid (SCFAs) and growth of beneficial
gut microbes. To determine the bioactivity of corn resistant starch (CRS) in diet-induced obesity, mice were fed a normal diet (ND), or a high-fat diet (HFD)
with or without CRS in this study. We demonstrated that CRS intervention mitigated HFD-induced body weight gain and adipocyte hypertrophy, 20% CRS in
particular; meanwhile, obesity-related physiological indices, including dyslipidemia, hepatic steatosis, insulin resistance and impaired glucose tolerance, were
improved after CRS intervention. Moreover, CRS intervention alleviated the extent of inflammation in epididymal white adipose tissues and liver tissues, as
opposed to those fed an HFD. On the other hand, CRS intervention reverted the gut microbiota composition disrupted by HFD feeding, with an increase in
Bacteroidetes and a decrease in Firmicutes. Using 16S rRNA gene sequencing of fecal samples, we observed the relative abundances of Muribaculaceae
increased significantly after CRS intervention, along with increased SCFA concentrations, correlated with its role in production of SCFAs; meanwhile,
endogenous probiotics Lactobacillaceae and Bifidobacteriaceae were raised, compared to HFD feeding alone. Taken together, the bioactivity of CRS in
diet-induced obesity includes averting the progression of obesity-related metabolic disorders and reshaping the gut microbiota composition to a state
before HFD feeding. The resulting data demonstrated the potential of CRS to be developed as a type of prebiotics and functional foods.
知識樹分類
消費者知識庫 > 農藝類
消費者知識庫 > 農業經濟與推廣類
消費者知識庫 > 食品科學類
消費者知識庫 > 生命科學類
相關檔案下載
- 桃園區農情月刊---第245期-------------政策宣導~推廣調高農漁民子女獎助學金海報113/04/19
- 桃園區農情月刊---第245期-------------政策宣導~推廣補助農友購置大型小型農機113/04/19
- 桃園區農情月刊---第245期-------------政策宣導~看天吃飯太辛苦,農業保險幫忙降損失113/04/19
- 桃園區農情月刊---第245期-------------政策宣導~「客家浪漫台三線計畫」政策溝通電子文宣113/04/19
- 桃園區農情月刊---第245期-------------109年1月主要 作物病蟲害預測113/04/19
- 桃園區農情月刊---第245期-------------本場新進人員介紹113/04/19
- 桃園區農情月刊---第245期-------------看見茶花新品種- 臺中科博館茶花品種展113/04/19
- 桃園區農情月刊---第245期-------------電子新貴~返鄉從農~走進稻香的世界113/04/19
- 桃園區農情月刊---第245期-------------桃園青農機械人力互助,創新服務帶動產業新活力-2113/04/19
- 桃園區農情月刊---第245期-------------桃園青農機械人力互助,創新服務帶動產業新活力-1113/04/19